I admit, i was too confident in my SQL, however that changed after seeing the interview questions that could be asked from different angle, the most important thing i have learnt in this course is CTE, and her Sunday SQL videos on YouTube is icing on cake. Natl Acad. Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. Her motto to live by is "Always minimize effort and maximize outcome!". Google Scholar. This suggests that genetic links between southern and southwestern European hunter-gatherers around the time of the LGM extended north of the Pyrenees. Moreover, the Oberkassel cluster carries both Villabruna ancestry and a contribution from GoyetQ2 ancestry (Supplementary Data 2.J). The long-lasting genetic continuity in Iberia is also reflected in the preservation until the Mesolithic of Y-chromosome haplogroup C, which was predominant in pre-LGM groups but rarely found after the LGM in other parts of Europe (Extended Data Figs. Were dedicated to providing you the best ofNews, with a focus on dependability andBusiness. Genomic insights into the origin of farming in the ancient Near East. This is . An early modern human from Romania with a recent Neanderthal ancestor. The Neolithic transition in the Baltic was not driven by admixture with early European farmers. Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracilDNAglycosylase treatment for screening of ancient DNA. The key areas to focus on when getting started in data science [6:01] Tina's five steps to consistently doing anything [11:55] Tina's day-to-day life as a data scientist at one of the world's largest tech companies [20:02] How Tina's computer science background helps her work [26:20] Traditional banking culture vs big tech [32:12] ISSN 0028-0836 (print). Reads with a mapping quality below 30 were then filtered with samtools, and the consensus sequences were generated by Schmutzi69. Tina is proud she taught herself SQL from scratch in 11 days to pass her FAANG SQL interview. A total of 23 patients that had operations in a . 4, 11 (2007). of estimates from 5-cM-block jackknife analysis. 255, 106796 (2021). Life During Adulthood: Should One Get Credit Cards? My name is Tina Huang and Im a data scientist at a FAANG company. CNRS, MNHN, Universit de Paris Cit, Muse de lHomme, Paris, France, PALEVOPRIM Lab UMR 7262 CNRS-INEE, University of Poitiers, Poitiers, France, Centre de Valorisation des Collections Scientifiques, Universit de Poitiers, Mignaloux Beauvoir, France, Muses de PoitiersVille de Poitiers, Poitiers, France, Departamento de Geologa, Facultad de Ciencia y Tecnologa, Universidad del Pas Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain, Sociedad de Ciencias Aranzadi, Donostia-San Sebastian, Spain, Centro UCM-ISCIII de Investigacin sobre Evolucin y Comportamiento Humanos, Madrid, Spain, Institute of Archaeology, University of Rzeszw, Rzeszw, Poland, Foundation for Rzeszw Archaeological Centre, Rzeszw, Poland, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA, Department of Psychiatry, Harvard Medical School, Boston, MA, USA, Groninger Instituut voor Archeologie, Groningen University, Groningen, The Netherlands, Institute of Archaeology and Ethnology, Polish Academy of Science, Pozna, Poland, Institute of History, Archaeology and Ethnography, Dushanbe, Tajikistan, ArchaeoZOOlogy in Siberia and Central AsiaZooSCAn, CNRSIAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia, Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia, Grupo de I+D+i EVOADAPTA (Evolucin Humana y Adaptaciones durante la Prehistoria) Departamento de Ciencias Histricas, Universidad de Cantabria, Santander, Spain, Borja Gonzlez-Rabanal,Ana B. Marn-Arroyo&Lawrence G. Straus, Instituto Internacional de Investigaciones Prehistricas de Cantabria (IIIPC), Universidad de Cantabria-Gobierno de Cantabria-Banco Santander, Santander, Spain, Departamento de Biologa de Organismos y Sistemas, Universidad de Oviedo, Oviedo, Spain, Quaternary Environments and Humans, OD Earth and History of Life, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Caroline Polet,Ivan Jadin&Sbastien Villotte, Muses Royaux dArt et dHistoire, Bruxelles, Belgium, Institute of Historical Research, University of Girona, Catalonia, Spain, Joaquim Soler,Neus Coromina&Isaac Ruf, INRAP/UMR 8215 Trajectoires 21, Paris, France, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA, Department of Anthropology, University of New Mexico, Albuquerque, NM, USA, GoArchPal-GoArchon, Viville sous-les-Cotes, France, Archologie & Mnzkabinett, Universalmuseum Joanneum, Graz, Austria, Museum Das Dorf des Welan, Wllersdorf-Steinabrckl, Austria, Department of Humanities, University of Ferrara, Ferrara, Italy, National Museum of Antiquities, Leiden, The Netherlands, Faculty of Archaeology, Leiden University, Leiden, The Netherlands, Biogeology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Unit de Recherches Art, Archologie Patrimoine, Universit de Lige, Lige, Belgium, I.U. 365 Data Use Cases: Data Science and Product Development with Tina Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Piezonka, H. et al. Leveraging the substantially increased sample size, we investigated genetically distinct hunter-gatherer groups for allele frequencies at selected loci that are known to be associated with specific phenotypic traits in present-day Europeans (Fig. The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). Tina Huang Profile page. Ice Age survivors. Furthermore, the findings show that there had been no genetic exchange between contemporaneous hunter-gatherer populations in western and eastern Europe for more than 6,000 years. Sci. 9). The baseline of each population was determined using the average heterozygosity rate of individuals estimated from pseudo-diploid genotypes (Supplementary Data 1.E). Echinacea. What is Kagi Chart in Data Visualization? Correspondence to 4a). Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Compared with the genetic diversity observed among all analysed Gravettian-associated groups, Epigravettian-associated individuals show significantly lower amounts of genetic diversity (two-tailed t-test, P<0.001) (Fig. Wood, R. E. et al. 6). Chintalapati, M., Patterson, N. & Moorjani, P. The spatiotemporal patterns of major human admixture events during the European Holocene. When Gravettian-associated individuals are included in an admixture graph also featuring Kostenki 14, we find that Fournol 85 fits best as a sister lineage of Goyet Q116-1, whereas the Vstonice group is modelled as a mixture between a lineage related to the Sunghir group and one related to the Goyet Q116-1Fournol 85 branch (Fig. Commun. & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. J. Anthropol. This course is presenting itself as both a refresher and a challenge. Well be back on Friday so, if youre not already, get subscribed to the Brandwatch Bulletin right away. Substantially contaminated libraries as well as marginally contaminated libraries of individually analysed genomes were filtered to maintain reads showing postmortem DNA damage (Methods and Supplementary Figs. Present-day individuals (gray dots) genotyped on theHumanOrigins dataset are used to define the PCA variation onto which ancient genomes (coloured symbols) are projected. de Investigacin en Arqueologa y Patrimonio Histrico, University of Alicante, Sant Vicent del Raspeig, Alicante, Spain, Javier Fernndez-Lpez de Pablo&Magdalena Gmez-Puche, Amsterdam Centre of Ancient Studies and Archaeology, University of Amsterdam, Amsterdam, The Netherlands, Department of Anatomy, Histology and Anthropology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Service Rgional de lArchologie de Bourgogne-Franche-Comt, Besanon Cedex, France, Laboratoire de Chrono-Environnement, UMR 6249 du CNRS, UFR des Sciences et Techniques, Besanon Cedex, France, Institute of Pre- and Protohistory, University of Tbingen, Tbingen, Germany, Department of Archeological Sciences, Thuringian State Office for Monuments Preservation and Archeology, Weimar, Germany, University of Bucharest, Faculty of Geology and Geophysics, Department of Geology, Bucharest, Romania, Institute for Advanced Studies in Levant Culture and Civilization, Bucharest, Romania, German Archaeological Institute, Berlin, Germany, Brandenburg Authorities for Heritage Management and Archaeological State Museum, Zossen, Germany, Institute for Pre- and Protohistory, Kiel University, Kiel, Germany, Institute of Archeology at Brno, Czech Academy of Sciences, Centre for Palaeolithic and Paleoanthropology, Brno, Czechia, Institute of Archaeology, Academy of Sciences of the Republic of Tatarstan, Kazan, Russia, Samara State University of Social Sciences and Education, Samara, Russia, Early Prehistory and Quaternary Ecology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Paleoanthropology, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, DFG Centre for Advanced Studies Words, Bones, Genes, Tools, University of Tbingen, Tbingen, Germany, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Institute of Archaeology Russian, Academy of Sciences, Moscow, Russia, School of Archaeology, University of Oxford, Oxford, UK, Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Saint Petersburg, Russia, Department of Cultures, University of Helsinki, Helsinki, Finland, Seminar for Pre- and Protohistory, Gttingen University, Gttingen, Germany, Lower Saxony State Service for Cultural Heritage, Hannover, Germany, Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, You can also search for this author in The dates were calibrated using OxCal 4.452 with calibration curve IntCal20 at 95.4% probability53 and when multiple dates were available for the same individual we used the function R_Combine to combine them52. The tentative placements of low-coverage ancient individuals based on their haplogroup assignment (Supplementary Data 1.A) are indicated with arrows on the respective branches. a, Geographic locations of newly reported individuals (filled symbols with black outline) and representative previously published individuals (outlined stars). Additional details are provided in SupplementaryInformation, section11 and SupplementaryTable 3. 4b and Supplementary Data 3.C). Colour legend is shown in (e). Liet. 15-star ratings) or unstructured data (such as social media reviews). Article The ethane yield of 35.4 mol/h with a high C 2 . Happy International Womens Day! Narasimhan, V. M. et al. After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. Curr. C. Posth, H.Y., A.G., A.B.R., W.H. Proc. Tina Huang - Data Scientist - Children's Hospital Los Angeles (CHLA 38. 3a and Supplementary Fig. Nature 513, 409413 (2014). Its not just the top 200 that this competition attracts, but anyone interested in data science. Both of these books focus on the science and math behind data mining. "Ice Age survivors." Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. Its no surprise that she was selected for the Code Cup, a yearly event where students from all over the world compete in coding challenges. At the same time, these two groups started mixing with each other, and continued to do so for around 3,000 years," Krause says. She then pursued a Masters . After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig. Ancient genomes indicate population replacement in Early Neolithic Britain. Therefore, as previously reported2, the Vstonice cluster itself results from admixture between western and eastern lineages, which might contribute to the observed homogeneity in cranial morphology among Gravettian-associated individuals22. Tina Huang - Instructor | 365 Data Science Ecol. Science 365, eaat7487 (2019). This course is the perfect balance of teaching technical SQL concepts and optimal approaches to solving coding questions on interviews. It involves lots of hypothesis testing and statistics which 365 Data Science also has a wonderful course on. Sci. Data warehousing is a field where you often have to deal with a lot of raw data. In product development, 80% of the success of a product is determined by 20% of its features. 5 and Extended Data Fig. Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. Extended Data Fig. Ecol. Details on individuals involved in the analysis, read counts processing and allele frequency computation are provided in the Supplementary Information, section12 and Supplementary Data 1.J and 3.G. 12 Data Science YouTube Channels by Women to Follow Nature 528, 499503 (2015). A user manual including an installation guide is available at https://haproh.readthedocs.io/en/latest/hapROH_with_contamination.html. The nuclear DNA contamination was estimated with several methods. Science 328, 710722 (2010). Huang, Y. Branch labels show unique drift lengths; black dots refer to individuals with newly generated data and white dots refer topreviously published genomes;the position of each node does not imply the location where the split took place. Low latency, reasonably low communication overhead and ability to support real time applications are the reasons for . Xinhe Huang - Teaching Assistant - Cardiff University / Prifysgol H. Rougier and I.C. Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. I have been watching Tina's YouTube channel's videos since the past month and find her explanations / reviews very useful and actionable and being in Toronto myself I think it will be same contextually when I start applying for DSc jobs (and make the big switch from Healthcare that I am in currently). Citing . No need to do it alone our community of learners and instructors is there for you. Become an in-demand #DataScience professional TODAY with the 365 Data Science Program -> https://365datascience.com, analyzing similar products to compare how they performed, data visualizations with SQL and Python or R. In other words, youll never have to worry about validity issues or having to re-take the course after a certain amount of time. 4. For the DNA lysis, a solution of 900l EDTA, 75l H2O and 25l proteinase K was added. 771234-PALEoRIDER (to W.H. Then pseudo-haploid genotypes were called using pileupCaller 1.4.0.2 (https://github.com/stschiff/sequenceTools) under random haploid calling mode. 40,000-year-old individual from Asia provides insight into early population structure in Eurasia. Cardiff, Wales, United Kingdom. Jnsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F. & Orlando, L. MapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. 1999 - 20001 year. Remember, its the problem that defines the tools we use! ScienceDaily, 1 March 2023. Curr. The Gravettian culture was one of the most widely distributed Upper Palaeolithic cultures across western Eurasia before the LGM19. The Roger Rabbit's Trousers (1990 film) Credits | JH Movie Collection She then served as a postdoctoral associate at the National Institute of Standards and Technology. Preistoria e Antropologia, Universit degli Studi di Siena, Siena, Italy, Stefano Ricci,Francesco Boschin&Annamaria Ronchitelli, Centro Studi sul Quaternario ODV, Sansepolcro, Italy, Institut National de Recherches Archologiques, Bertrange, Luxembourg, Department of Cultural Heritage, University of Bologna, Ravenna, Italy, Gregorio Oxilia,Eugenio Bortolini,Stefano Benazzi&Matteo Romandini, Human Ecology and Archaeology (HUMANE), Department of Archaeology and Anthropology, Instituci Mil i Fontanals de Investigacin en Humanidades, Consejo Superior de Investigaciones Cientficas (IMF - CSIC), Barcelona, Spain, UMR 7209Archozoologie et Archobotanique-Socits, Pratiques et Environnements, Musum National dHistoire Naturelle, Paris, France, Dipartimento di Scienze Della Vita e DellAmbiente, Sezione di Neuroscienze e Antropologia, Universit Degli Studi di Cagliari, Cittadella Monserrato, Cagliari, Italy, Dipartimento di Civilt e Forme Del Sapere, Universit di Pisa, Pisa, Italy, Center for Isotope Research, Groningen University, Groningen, The Netherlands, UMR 7206 co-Anthropologie, quipe ABBA. Metadata information of studied individuals. Schmitt, T. Molecular biogeography of Europe: Pleistocene cycles and postglacial trends. Consistent with previous findings, none of the analysed groups show the derived allele at SNP rs4988235 on the LCT gene, which is responsible for lactase persistence. Some of those early groups from more than 40ka further admixed with Neanderthals, as shown by signals of recent introgression in individuals from Bacho Kiro in Bulgariaassociated with an Initial Upper Palaeolithic (IUP) archaeological cultureand from Petera cu Oase in Romania2,6. Rep. 10, 21931 (2020). In anticipation of possible near-term approval from the US Food and Drug Administration for renal denervation, there must be an insistence on longer-term clinical outcomes and safety data. Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. The sequence alignment/map format and SAMtools. The formation of human populations in South and Central Asia. Edgar, R. C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. Bioinformatics 29, 16821684 (2013). The pathway program not only helps students to strengthen their English, but more importantly, it helps students to understand and adapt to the expections of university.". 365 Data Use Cases: Data Science and Product Development with Tina Huang This may have prompted people from the south to expand their habitat. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. I have an undergraduate degree in pharmacology from the University of Toronto. Details of the grouping and ROH segments are provided in Data S3.B. Individuals at this site might mark one of the last occurrences of such high levels of hunter-gatherer-related ancestries, just centuries before the emerging European Bronze Age. Instead, for the two SNPs associated with skin colour (SLC24A5 (rs1426654) and SLC45A2 (rs16891982)), Sidelkino clusterand Ukraine HG groups show a higher frequency (>90% for SLC24A5 and 2961% for SLC45A2) of the derived alleles related to light skin colour, compared with Oberkassel and Villabruna clusters, where those alleles are almost completely absent (<1%). hellotinah F-statistics suggest that Le Piage II is genetically intermediate between Fournol 85 and El Mirn (Supplementary Data 2.D). Its mainly used in industries such as finance, insurance, healthcare, and insurance-related apps such as credit card applications, vehicle purchasing, etc. Find contact's direct phone number, email address, work history, and more. & Vernot, B. Samples with a percentage of human DNA in shotgun data around 0.1% or greater were enriched for a set of 1,237,207 targeted SNPs (1240k capture) across the human genome6. Li, H. et al. Former Apple and Twitter Engineer Explains Why She Started - Insider Nat. Olalde, I. Proc. Billed once. A.G.-O. View Tina_Huang_Resume_i.pdf from HCI 445 at DePaul University. This article reviews qualitative and quantitative studies related to the academic achievement of youth from immigrant Chinese families. 7, eabd6535 (2021). Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). and JavaScript. Tina is excellent when it comes to getting overall data science career advice. Jensen, T. Z. T. et al. Created by DataSciencePR. Evol. 5). . Genomic structure in Europeans dating back at least 36,200 years. In the box plot the centre line is the median, box bounds delineate the interquartile range and whiskers extend to maximum and minimum values, excluding outliers. H. Rougier received support from the College of Social and Behavioral Sciences of CSUN and the CSUN Competition for RSCA Awards. Modern humans left sub-Saharan Africa at least 60 thousand years ago (ka), and during their initial expansion into Eurasia, they genetically mixed with Neanderthals, resultingin 23% Neanderthal ancestry in the majority of present-day non-African populations5. PubMed If you are interested in the full curriculum offered on our platform or would like to enroll in a more extensive career track, consider continuing your data science journey with one of our subscription plans today! 211 and Supplementary Table 1). To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. Error bars show 1s.e.m. . Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. L. Sineo, M.L. Lifetime access to all course materials and updates. The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). Google Scholar. Interactions between people from central and eastern Europe can only be detected again from 8,000 years ago.

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